You may have heard of Kaspersky Rescue Disk which can be used to boot up a computer and scans the hard drive for viruses without even loading Windows. This is very useful when the computer is badly infected by malware and causing Windows unable to boot or is really too slow to do anything. Recently I discovered another free tool offered by Kaspersky called WindowsUnlocker which is useful in neutralizing complicated malware such as a ransomware that makes your computer unusable until you follow the on-screen instruction to transfer money in order to get the unlock code. The smarter ransomware starts automatically when Windows is booted up and even in Safe Mode, automatically prevent explorer.exe from starting and also blocking vital hotkeys such as CTRL+SHIFT+ESC to launch Task Manager which can be used to kill the ransomware process or manually run explorer.exe.
When all hope is lost, Kaspersky WindowsUnlocker can be used to fix the registry to stop the ransomware from automatically being loaded when Windows is booted up. It does not touch any of the files on your computer other than the registry. Once Windows can be started up normally, you can use a good antivirus to perform a full scan and remove any found malwares.